Mechanisms of Mitotic Spindle Assembly
نویسندگان
چکیده
منابع مشابه
Membrane-based mechanisms of mitotic spindle assembly
Chromosome segregation during mitosis is mediated by the mitotic spindle. Formation of this microtubular structure relies on distinct processes such as microtubule nucleation and growth and the consequent focusing of these filaments into spindle poles. Here, we discuss our recent finding that a size-exclusion spindle envelope promotes mitotic fidelity in Drosophila cells in light of distinct sp...
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In textbooks, the mitotic spindles of plants are often described separately from those of animals. How do they differ at the molecular and mechanistic levels? In this chapter, we first outline the process of mitotic spindle assembly in animals and land plants. We next discuss the conservation of spindle assembly factors based on database searches. Searches of >100 animal spindle assembly factor...
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Ran is an abundant nuclear GTPase with a clear role in nuclear transport during interphase but with roles in mitotic regulation that are less well understood. The nucleotide-binding state of Ran is regulated by a GTPase activating protein, RanGAP1, and by a guanine nucleotide exchange factor, RCC1. Ran also interacts with a guanine nucleotide dissociation inhibitor, RanBP1. RanBP1 has a high af...
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Cooperativity is well known to promote the speed of some biochemical reactions by accelerating the activity of enzymes. Recent studies have shown that cooperative interactions also function during the formation of a complex cellular structure, the mitotic spindle. Capture of kinetochores by dynamic astral microtubules was originally proposed as the basis of spindle formation. However, mounting ...
متن کاملMechanisms and Molecules of the Mitotic Spindle
In all eukaryotes, morphogenesis of the microtubule cytoskeleton into a bipolar spindle is required for the faithful transmission of the genome to the two daughter cells during division. This process is facilitated by the intrinsic polarity and dynamic properties of microtubules and involves many proteins that modulate microtubule organization and stability. Recent work has begun to uncover the...
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ژورنال
عنوان ژورنال: Annual Review of Biochemistry
سال: 2016
ISSN: 0066-4154,1545-4509
DOI: 10.1146/annurev-biochem-060815-014528